Essential statistical principles of clinical trials of pain treatments

Statistical Principles of Clinical Trials Lecture

Evaluation of Clinical Trials

In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...

The Effect of Fennel on Pain Relief in Primary Dysmenorrhea: A Systematic Review of Clinical Trials

Background and aims: Fennel is often advocated for primary dysmenorrhea. Whether this herb has areal effect on pain relief is still a matter of debate in medicine. Therefore, this study was conducted toevaluate the effect of fennel on primary dysmenorrhea.Methods: This systematic review was conducted on clinical trials (non-randomized, randomized,historical study with co...

Statistical Aspects of Clinical Trials

My object in this lecture will be to give an overview of the statistical aspects of current clinical trial methodology, including a very brief history, my view of current practice, recent relevant statistical developments, and areas that need further statistical research. My primary concern will be clinical experiments, though I will have some comments on other types of study of clinical data a...

comparative study of pain relieving effect of dry cotton pellet and eugenol cotton pellet in the reduction of pain in emergoney pulpotomy

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